Collection of Engaged Learning
Contributor(s)
Dr. Peng Tao
Publication Date
4-15-2014
Abstract
Nitric oxide (NO) is a critical cell-signaling messenger in the immune, cardiovascular, and nervous systems. It is linked to several diseases, and due to its high reactivity, and toxicity as a free radical, NO possesses a controversial effect on cell viability. The S-nitrosylation of protein thiol groups is a key mechanism in NO redox signal transduction, and lends a mechanistic basis for NO as a cell regulator. Numerous experiments have shown that the rate-limiting step of S-nitrosylation is NO autoxidation, independent of thiol concentration. Due to the transient nature, and structural variety of reactive nitrogen species, very little is known about the mechanisms of either NO autoxidation or S-nitrosylation.
Document Type
Article
Keywords
Engaged Learning 2014
Disciplines
Chemistry | Other Chemistry | Physical Sciences and Mathematics
Part of
Extent
8 pages
Format
Rights
The files in this collection are protected by copyright law. No commercial reproduction or distribution of these files is permitted without the written permission of Southern Methodist University, Cox Business School. These files may be freely used for educational purposes, provided they are not altered in any way, and Southern Methodist University is cited. For more information, contact ncds@smu.edu.
Language
English
Recommended Citation
Abusad, Yazen, "Computational Study of the Nitric Oxide Autoxidation Mechanism Using Quantum Chemistry Methods" (2014). Collection of Engaged Learning. 33.
https://scholar.smu.edu/upjournal_research/33
